Publications

2023

Journal Articles

From cellular to fear memory: An epigenetic toolbox to remember

D. M. Coda; J. Graeff 

Current Opinion In Neurobiology. 2023-12-20. Vol. 84, p. 102829. DOI : 10.1016/j.conb.2023.102829.

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Prenatal stress aggravates age-dependent cognitive decline, insulin signaling dysfunction, and the pro-inflammatory response in the APPNL-F/ NL-F mouse model of Alzheimer’s disease

E. Trojan; K. Curzytek; P. Cieslik; J. M. Wieronska; J. Graff et al. 

Neurobiology Of Disease. 2023-08-01. Vol. 184, p. 106219. DOI : 10.1016/j.nbd.2023.106219.

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Prefrontal engrams of long-term fear memory perpetuate pain perception

A. Stegemann; S. Liu; O. A. Retana Romero; M. J. Oswald; Y. Han et al. 

Nature Neuroscience. 2023-04-06. DOI : 10.1038/s41593-023-01291-x.

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Reviews

Tissue clearing applications in memory engram research

K. Y. T. Yip; J. Graff 

Frontiers In Behavioral Neuroscience. 2023-08-28. Vol. 17, p. 1181818. DOI : 10.3389/fnbeh.2023.1181818.

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Face your fears: attenuating remote fear memories by reconsolidation-updating

B. A. Silva; J. Graff 

Trends In Cognitive Sciences. 2023-03-14. Vol. 27, num. 4, p. 404-416. DOI : 10.1016/j.tics.2023.01.004.

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Nutritional metabolism and cerebral bioenergetics in Alzheimer’s disease and related dementias

H. N. Yassine; W. Self; B. E. Kerman; G. Santoni; N. N. Shanmugam et al. 

Alzheimers & Dementia. 2023. Vol. 19, num. 3, p. 1041-1066. DOI : 10.1002/alz.12845.

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2022

Journal Articles

The HDAC inhibitor CI-994 acts as a molecular memory aid by facilitating synaptic and intracellular communication after learning

A. M. Burns; M. Farinelli-Scharly; S. Hugues-Ascery; J. V. Sanchez-Mut; G. Santoni et al. 

Proceedings of the National Academy of Sciences. 2022-05-25. Vol. 119, num. 22, p. 1-12, e2116797119. DOI : 10.1073/pnas.2116797119.

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Brain-wide screen of prelimbic cortex inputs reveals a functional shift during early fear memory consolidation

L. Dixsaut; J. Gräff 

eLife. 2022-07-15. Vol. 11. DOI : 10.7554/eLife.78542.

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Inquiring the librarian about the location of memory

G. Berdugo-Vega; J. Graeff 

Cognitive Neuroscience. 2022-05-16. DOI : 10.1080/17588928.2022.2076075.

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2021

Journal Articles

A thalamo-amygdalar circuit underlying the extinction of remote fear memories

B. A. Silva; S. Astori; A. M. Burns; H. Heiser; L. van den Heuvel et al. 

Nature Neuroscience. 2021-05-20. Vol. 24, p. 964–974. DOI : 10.1038/s41593-021-00856-y.

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Reviews

The Medial Prefrontal Cortex and Fear Memory: Dynamics, Connectivity, and Engrams

L. Dixsaut; J. Graeff 

International Journal Of Molecular Sciences. 2021-11-01. Vol. 22, num. 22, p. 12113. DOI : 10.3390/ijms222212113.

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2020

Journal Articles

Membrane activity detection in cultured cells using phase-sensitive plasmonics

F. Sohrabi; Y. Jahani; J. V. Sanchez-Mut; E. Mohammadi; Z. Barzegar et al. 

Optics Express. 2020-11-23. Vol. 28, num. 24, p. 36643-36655. DOI : 10.1364/OE.399713.

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Cognitive epigenetic priming: leveraging histone acetylation for memory amelioration

A. Burns; J. Gräff 

Current Opinion in Neurobiology. 2020-10-26. Vol. 67, p. 75-84. DOI : 10.1016/j.conb.2020.08.011.

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Comprehensive analysis of PM20D1 QTL in Alzheimer’s disease

J. V. Sanchez-Mut; L. Glauser; D. Monk; J. Graff 

Clinical Epigenetics. 2020-02-03. Vol. 12, num. 1, p. 20. DOI : 10.1186/s13148-020-0814-y.

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Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency

A. Bacq; S. Astori; E. Gebara; W. Tang; B. A. Silva et al. 

Mol Psychiatry. 2020. Vol. 25, num. 9, p. 2144-61. DOI : 10.1038/s41380-018-0132-3.

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2019

Journal Articles

Psychotropic drug-induced genetic-epigenetic modulation of CRTC1 gene is associated with early weight gain in a prospective study of psychiatric patients

A. Delacretaz; A. Glatard; C. Dubath; M. Gholam-Rezaee; J. V. Sanchez-Mut et al. 

Clinical Epigenetics. 2019-12-26. Vol. 11, num. 1, p. 198. DOI : 10.1186/s13148-019-0792-0.

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Reactivation of Recall-Induced Neurons in the Infralimbic Cortex and the Basolateral Amygdala After Remote Fear Memory Attenuation

O. Khalaf; J. Graff 

Frontiers In Molecular Neuroscience. 2019-04-17. Vol. 12, p. 70. DOI : 10.3389/fnmol.2019.00070.

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Engram Excitement

Z. Albo; J. Graff 

Neuron. 2019-01-16. Vol. 101, num. 2, p. 198-200. DOI : 10.1016/j.neuron.2018.12.033.

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A cFos activation map of remote fear memory attenuation

B. A. Silva; A. M. Burns; J. Gräff 

Psychopharmacology. 2019. Vol. 236, num. 1, p. 369-381. DOI : 10.1007/s00213-018-5000-y.

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2018

Journal Articles

Reactivation of recall-induced neurons contributes to remote fear memory attenuation

O. Khalaf; S. Resch; L. Dixsaut; V. Gorden; L. Glauser et al. 

Science. 2018-06-15. Vol. 360, num. 6394, p. 1239-1242. DOI : 10.1126/science.aas9875.

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PM20D1 is a quantitative trait locus associated with Alzheimer’s disease

J. V. Sanchez-Mut; H. Heyn; B. A. Silva; L. Dixsaut; P. Garcia-Esparcia et al. 

Nature Medicine. 2018. Vol. 24, num. 5, p. 598-603. DOI : 10.1038/s41591-018-0013-y.

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Reviews

The mysteries of remote memory

Z. Albo; J. Gräff 

Philosophical Transactions of the Royal Society B: Biological Sciences. 2018. Vol. 373, num. 1742, p. 20170029. DOI : 10.1098/rstb.2017.0029.

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Patents

Methods of diagnosis alzheimer’s disease

J. V. Sanchez Mut; J. Gräff; H. Heyn; M. Esteller Badosa 

EP3488013; US2019233894; EP3488013; WO2018015291; EP3272878.

2018.

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2017

Journal Articles

Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons

L. Frangeul; V. Kehayas; J. V. Sanchez Mut; S. Fièvre; K. Krishna-K et al. 

Nature Communications. 2017-12-08. Vol. 8, num. 1, p. 2015. DOI : 10.1038/s41467-017-02172-1.

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FORMINg a link between PTSD and AD

J. Gräff 

Embo Journal. 2017. Vol. 36, num. 19, p. 2809-2811. DOI : 10.15252/embj.201798013.

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Whole genome grey and white matter DNA methylation profiles in dorsolateral prefrontal cortex

J. V. Sanchez-Mut; H. Heyn; E. Vidal; R. Delgado-Morales; S. Moran et al. 

Synapse. 2017. Vol. 71, num. 6, p. e21959. DOI : 10.1002/syn.21959.

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2016

Journal Articles

Cortical neurons gradually attain a post-mitotic state

F. C. d. Anda; R. Madabhushi; D. Rei; J. Meng; J. Gräff et al. 

Cell research. 2016. Vol. 26, p. 1033-1047. DOI : 10.1038/cr.2016.76.

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Balancing family with a successful career in neuroscience

P. Poirazi; D. Belin; J. Gräff; I. Hanganu-Opatz; G. López-Bendito 

The European journal of neuroscience. 2016. Vol. 44, num. 2, p. 1797-1803. DOI : 10.1111/ejn.13280.

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Reviews

The neural circuits of innate fear: detection, integration, action, and memorization

B. A. Silva; C. T. Gross; J. Gräff 

Learning & memory (Cold Spring Harbor, N.Y.). 2016. Vol. 23, num. 10, p. 544-55. DOI : 10.1101/lm.042812.116.

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Structural, Synaptic, and Epigenetic Dynamics of Enduring Memories

O. Khalaf; J. Gräff 

Neural plasticity. 2016. Vol. 2016, p. 3425908. DOI : 10.1155/2016/3425908.

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2015

Journal Articles

Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway

D. Rei; X. Mason; J. Seo; J. Gräff; A. Rudenko et al. 

Proceedings of the National Academy of Sciences of the United States of America. 2015. Vol. 112, num. 23, p. 7291-7296. DOI : 10.1073/pnas.1415845112.

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Reviews

Epigenetic Alterations in Alzheimer’s Disease

J. Sanchez-Mut; J. Gräff 

Frontiers In Behavioral Neuroscience. 2015. Vol. 9, p. 347. DOI : 10.3389/fnbeh.2015.00347.

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2014

Journal Articles

Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories

J. Gräff; N. F. Joseph; M. E. Horn; A. Samiei; J. Meng et al. 

Cell. 2014. Vol. 156, num. 1-2, p. 261-76. DOI : 10.1016/j.cell.2013.12.020.

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Reviews

On the resilience of remote traumatic memories against exposure therapy-mediated attenuation

L-H. Tsai; J. Gräff 

EMBO reports. 2014. Vol. 15, num. 8, p. 853-861. DOI : 10.15252/embr.201438913.

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2013

Journal Articles

A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration

J. Gräff; M. Kahn; A. Samiei; J. Gao; K. T. Ota et al. 

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013. Vol. 33, num. 21, p. 8951-60. DOI : 10.1523/JNEUROSCI.5657-12.2013.

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Reviews

The potential of HDAC inhibitors as cognitive enhancers

J. Gräff; L-H. Tsai 

Annual review of pharmacology and toxicology. 2013. Vol. 53, p. 311-30. DOI : 10.1146/annurev-pharmtox-011112-140216.

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Histone acetylation: molecular mnemonics on the chromatin

J. Gräff; L-H. Tsai 

Nature reviews. Neuroscience. 2013. Vol. 14, num. 2, p. 97-111. DOI : 10.1038/nrn3427.

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2012

Journal Articles

An epigenetic blockade of cognitive functions in the neurodegenerating brain

J. Gräff; D. Rei; J-S. Guan; W-Y. Wang; J. Seo et al. 

Nature. 2012. Vol. 483, num. 7388, p. 222-6. DOI : 10.1038/nature10849.

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Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex

F. Calderon de Anda; A. L. Rosario; O. Durak; T. Tran; J. Gräff et al. 

Nature neuroscience. 2012. Vol. 15, num. 7, p. 1022-31. DOI : 10.1038/nn.3141.

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Dynamic histone marks in the hippocampus and cortex facilitate memory consolidation

J. Gräff; B. T. Woldemichael; D. Berchtold; G. Dewarrat; I. M. Mansuy 

Nature Communications. 2012. Vol. 3, p. 991. DOI : 10.1038/ncomms1997.

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2011

Journal Articles

Nuclear protein phosphatase-1: an epigenetic regulator of fear memory and amygdala long-term potentiation

K. Koshibu; J. Gräff; I. M. Mansuy 

Neuroscience. 2011. Vol. 173, p. 30-6. DOI : 10.1016/j.neuroscience.2010.11.023.

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Cognitive enhancement: A molecular memory booster

J. Gräff; L-H. Tsai 

Nature. 2011. Vol. 469, num. 7331, p. 474-5. DOI : 10.1038/469474a.

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Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1)

P. Giusti-Rodríguez; J. Gao; J. Gräff; D. Rei; T. Soda et al. 

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011. Vol. 31, num. 44, p. 15751-6. DOI : 10.1523/JNEUROSCI.3588-11.2011.

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Reviews

Epigenetic regulation of gene expression in physiological and pathological brain processes

J. Gräff; D. Kim; M. M. Dobbin; L-H. Tsai 

Physiological reviews. 2011. Vol. 91, num. 2, p. 603-49. DOI : 10.1152/physrev.00012.2010.

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Book Chapters

Epigenetics of brain disorders

J. Gräff; T. B. Franklin; I. M. Mansuy 

Handbook of Epigenetics; Amsterdam: Elsevier, 2011. p. 553-567.

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2010

Journal Articles

Epigenetic transmission of the impact of early stress across generations

T. B. Franklin; H. Russig; I. C. Weiss; J. Gräff; N. Linder et al. 

Biological psychiatry. 2010. Vol. 68, num. 5, p. 408-15. DOI : 10.1016/j.biopsych.2010.05.036.

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A novel pathway regulates memory and plasticity via SIRT1 and miR-134

J. Gao; W-Y. Wang; Y-W. Mao; J. Gräff; J-S. Guan et al. 

Nature. 2010. Vol. 466, num. 7310, p. 1105-9. DOI : 10.1038/nature09271.

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Protein phosphatase 1-dependent transcriptional programs for long-term memory and plasticity

J. Gräff; K. Koshibu; A. Jouvenceau; P. Dutar; I. M. Mansuy 

Learning & memory (Cold Spring Harbor, N.Y.). 2010. Vol. 17, num. 7, p. 355-63. DOI : 10.1101/lm.1766510.

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2009

Journal Articles

Protein phosphatase 1 regulates the histone code for long-term memory

K. Koshibu; J. Gräff; M. Beullens; F. D. Heitz; D. Berchtold et al. 

The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009. Vol. 29, num. 41, p. 13079-89. DOI : 10.1523/JNEUROSCI.3610-09.2009.

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Reviews

Epigenetic dysregulation in cognitive disorders

J. Gräff; I. M. Mansuy 

The European journal of neuroscience. 2009. Vol. 30, num. 1, p. 1-8. DOI : 10.1111/j.1460-9568.2009.06787.x.

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2008

Reviews

Epigenetic codes in cognition and behaviour

J. Gräff; I. M. Mansuy 

Behavioural brain research. 2008. Vol. 192, num. 1, p. 70-87. DOI : 10.1016/j.bbr.2008.01.021.

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2007

Journal Articles

An annotated cDNA library and microarray for large-scale gene-expression studies in the ant Solenopsis invicta

J. Wang; S. Jemielity; P. Uva; Y. Wurm; J. Gräff et al. 

Genome biology. 2007. Vol. 8, num. 1, p. R9. DOI : 10.1186/gb-2007-8-1-r9.

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Differential gene expression between adult queens and workers in the ant Lasius niger

J. Gräff; S. Jemielity; J. D. Parker; K. M. Parker; L. Keller 

Molecular ecology. 2007. Vol. 16, num. 3, p. 675-83. DOI : 10.1111/j.1365-294X.2007.03162.x.

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2006

Journal Articles

How to fool a virgin: Artificial dealation triggers oviposition in virgin Lasius niger queens

S. Jemielity; J. Gräff; L. Keller 

Insectes Sociaux. 2006. Vol. 53, num. 3, p. 323-325. DOI : 10.1007/s00040-006-0875-8.

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